[KO Validated] MEK2 Rabbit pAb (APR21320N)
产品名称: [KO Validated] MEK2 Rabbit pAb (APR21320N)
英文名称: [KO Validated] MEK2 Rabbit pAb (APR21320N)
产品编号: APR21320N
产品价格: null
产品产地: 美国
品牌商标: Leading Biology
更新时间: null
使用范围:
安诺伦(北京)生物科技有限公司
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- 地址 : 北京大兴经济技术开发区天骥智谷35A
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分子量:Calculated MW: 44kDa Observed MW: 45KDa 细胞定位:Cytoplasm, Membrane, Peripheral membrane protein 稀释方法:WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:50 - 1:200 总结:The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.