BAF250 Rabbit pAb (APR23245N)-抗体-抗体-生物在线
安诺伦(北京)生物科技有限公司
BAF250 Rabbit pAb (APR23245N)

BAF250 Rabbit pAb (APR23245N)

商家询价

产品名称: BAF250 Rabbit pAb (APR23245N)

英文名称: BAF250 Rabbit pAb (APR23245N)

产品编号: APR23245N

产品价格: null

产品产地: 美国

品牌商标: Leading Biology

更新时间: null

使用范围:

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分子量:Calculated MW: 206kDa/218kDa/242kDa
Observed MW: 260kDa

细胞定位:Nucleus

稀释方法:WB 1:500 - 1:2000

总结:This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene.